Research Area	Molecular cytogenetics, Chromosome biology
Google Scholar	Google Scholar
ResearchMap	https://researchmap.jp/hayama_nanafushi
E-mail	tanabe_hideyuki (at) soken.ac.jp

We explore how organisms evolve at the molecular level. The major focus is on the population process, where new mutations arise which are subsequently subject to selection and random genetic drift. We mainly use a theoretical approach to understand the evolutionary mechanisms behind inter- and intra-specific DNA variation under a wide range of evolutionary forces, such as adaptive selection, balancing selection, speciation, gene duplication. The accumulation of these studies promises to provide profound insights into the overarching principles governing molecular evolution.

Selected Publications, Books etc.

• 1.R. Kawamura, H. Tanabe, T. Wada, S. Saitoh, Y. Fukushima and K. Wakui* (2012) Visualization of the spatial positioning of the SNRPN, UBE3A, and GABRB3 genes in the normal human nucleus by three-color 3D fluorescence in situ hybridization. Chromosome Research 20, 659-672.
• 2.E. Ohfuchi-Maruyama, T. Hori, H. Tanabe*, H. Kitamura, R. Matsuda, S. Tone, P. Hozak, F. A. Habermann, J. von Hase, C. Cremer, T. Fukagawa and M. Harata* (2012) The actin family member Arp6 and the histone variant H2A.Z are required for spatial positioning of chromatin in chicken cell nuclei. Journal of Cell Science 125, 3739-3743.
• 3.T. Amano, T. Sagai, H. Tanabe, Y. Mizushina, H. Nakazawa and T. Shiroishi* (2009) Chromosomal dynamics at the Shh locus: Lim bud-specific differential regulation of competence and active transcription. Developmental Cell 16, 47-57.
• 4.H. Tanabe*, K. Küpper, T. Ishida, M. Neusser and H. Mizusawa (2005) Inter- and intra-specific gene-density correlated radial chromosome territory arrangements are conserved in Old World monkeys. Cytogenetic and Genome Research 108, 255-261.
• 5.H. Tanabe, S. Müller, M. Neusser, J. von Hase, E. Calcagno, M. Cremer, I. Solovei, C. Cremer and T. Cremer* (2002) Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates. Proceedings of the National Academy of Sciences USA 99, 4424-4429.